The association between PTPN22 C1858T gene polymorphism and type 1 diabetes mellitus: an Indonesian study.

ABSTRACT:

Background

Type 1 diabetes mellitus (T1DM) is disease caused by the destruction of β pancreatic cells. The activation of T-lymphocyte and proliferation inhibitor are induced by protein tyrosine phosphatase non-receptor type 22 (PTPN22). However, the link between PTPN22 C1858T gene polymorphism and T1DM is still controversy. This study aimed to analyse the C1858T gene polymorphism in Indonesian children with T1DM.

Materials and methods

This case-control study was conducted from March 2021 to May 2022 in the Endocrinology Outpatient Clinic at Dr. Soetomo Hospital and Tropical Disease Center Universitas Airlangga. Patients with controlled T1DM during the study period were included. The PTPN22 analysis used polymerase chain reaction restriction fragment leng

SUBMITTER: Rochmah N 

PROVIDER: S-EPMC10044151 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature