Investigation of enhanced intracellular delivery of nanomaterials modified with novel cell-penetrating zwitterionic peptide-lipid derivatives.

ABSTRACT: Functionalized drug delivery systems have been investigated to improve the targetability and intracellular translocation of therapeutic drugs. We developed high functionality and quality lipids that met unique requirements, focusing on the quality of functional lipids for the preparation of targeted nanoparticles using microfluidic devices. While searching for a lipid with high solubility and dispersibility in solvents, which is one of the requirements, we noted that KK-(EK)₄-lipid imparts nonspecific cellular association to polyethylene glycol (PEG)-modified (PEGylated) liposomes, such as cell-penetrating peptides (CPPs). We investigated whether KK-(EK)₄-lipid, which has a near-neutral charge, is a novel CPP-modified lipid that enhances the intracellular translocatio

SUBMITTER: Sugimoto Y 

PROVIDER: S-EPMC10044157 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature