Antibacterial and Antibiofilm Activities of β-Lapachone by Modulating the Catalase Enzyme.

ABSTRACT:

Background

Bacterial infections constantly have a large impact on public health, because of increased rates of resistance and reduced frequency of development of novel antibiotics. The utility of conventional antibiotics for treating bacterial infections has become increasingly challenging. The aim of the study was to assess the antibacterial effect of β-Lapachone (β-Lap), a novel synthetic compound.

Methods

The antibacterial activity of the β-Lap compound was examined against laboratory strains by agar well diffusion method and broth dilution assay. Growth kinetics in presence of β-Lap on Staphylococcus aureus, Staphylococcus epidermidis, and Pseudomonas aeruginosa (ATCC 27853) were assessed by microplate alamarBlue assay. Crystal violet blue assay was

SUBMITTER: Mir MA 

PROVIDER: S-EPMC10044350 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature