Identifying potential biomarkers for the diagnosis and treatment of IgA nephropathy based on bioinformatics analysis.

ABSTRACT:

Background

IgA nephropathy (IgAN) has become the leading cause of end-stage renal disease in young adults. Nevertheless, the current diagnosis exclusively relies on invasive renal biopsy, and specific treatment is deficient. Thus, our study aims to identify potential crucial genes, thereby providing novel biomarkers for the diagnosis and therapy of IgAN.

Methods

Three microarray datasets were downloaded from GEO official website. Differentially expressed genes (DEGs) were identified by limma package. GO and KEGG analysis were conducted. Tissue/organ-specific DEGs were distinguished via BioGPS. GSEA was utilized to elucidate the predominant enrichment pathways. The PPI network of DEGs was established, and hub genes were mined through Cytoscape. The CTD database was employed t

SUBMITTER: Li X 

PROVIDER: S-EPMC10044383 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature