Novel Arginine- and Proline-Rich Candidacidal Peptides Obtained through a Bioinformatic Approach.

ABSTRACT: Antimicrobial resistance is a major public health concern worldwide. Albeit to a lesser extent than bacteria, fungi are also becoming increasingly resistant to antifungal drugs. Moreover, due to the small number of antifungal classes, therapy options are limited, complicating the clinical management of mycoses. In this view, antimicrobial peptides (AMPs) are a potential alternative to conventional drugs. Among these, Proline-rich antimicrobial peptides (PrAMPs), almost exclusively of animal origins, are of particular interest due to their peculiar mode of action. In this study, a search for new arginine- and proline-rich peptides from plants has been carried out with a bioinformatic approach by sequence alignment and antimicrobial prediction tools. Two peptide candidates were tested agains

SUBMITTER: Ciociola T 

PROVIDER: S-EPMC10044544 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature