A serum protein signature at the time of Uveal Melanoma diagnosis predicts long-term patient survival.

ABSTRACT:

Purpose

To develop a prognostic test based on a single blood sample obtained at the time of uveal melanoma diagnosis.

Methods

83 patients diagnosed with posterior uveal melanoma between 1996 and 2000 were included. Peripheral serum samples were obtained at diagnosis and kept at -80 °C until this analysis. Protein profiling of 84 cancer-related proteins was used to screen for potential biomarkers and a prognostic test that stratifies patients into metastatic risk categories was developed (serUM-Px) in a training cohort and then tested in a validation cohort.

Results

Low serum leptin levels and high osteopontin levels were found to identify patients with poor prognosis and were therefore selected for inclusion in the final test. In the validation cohort, patient sex and

SUBMITTER: Herrspiegel C 

PROVIDER: S-EPMC10044715 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature