The Extracellular Matrix Vitalizer RA^TM Increased Skin Elasticity by Modulating Mitochondrial Function in Aged Animal Skin.

ABSTRACT: Oxidative stress-induced cellular senescence and mitochondrial dysfunction result in skin aging by increasing ECM levels-degrading proteins such as MMPs, and decreasing collagen synthesis. MMPs also destroy the basement membrane, which is involved in skin elasticity. The extracellular matrix vitalizer RA^TM (RA) contains various antioxidants and sodium hyaluronate, which lead to skin rejuvenation. We evaluated whether RA decreases oxidative stress and mitochondrial dysfunction, eventually increasing skin elasticity in aged animals. Oxidative stress was assessed by assaying NADPH oxidase activity, which is involved in ROS generation, and the expression of SOD, which removes ROS. NADPH oxidase activity was increased in aged skin and decreased by RA injection. SOD expression was dec

SUBMITTER: Byun KA 

PROVIDER: S-EPMC10044720 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature