Low expression of SLC34A1 is associated with poor prognosis in clear cell renal cell carcinoma.

ABSTRACT:

Objective

Clear cell renal cell carcinoma (ccRCC) is a malignant renal tumor that is highly prone to metastasis and recurrence. The exact pathogenesis of this cancer is still not well understood. This study aimed to identify novel hub genes in renal clear cell carcinoma and determine their diagnostic and prognostic value.

Methods

Intersection genes were obtained from multiple databases, and protein-protein interaction analysis and functional enrichment analysis were performed to identify key pathways related to the intersection genes. Hub genes were identified using the cytoHubba plugin in Cytoscape. GEPIA and UALCAN were utilized to observe differences in mRNA and protein expression of hub genes between KIRC and adjacent normal tissues. The Wilcoxon rank sum test was used t

SUBMITTER: Qiu J 

PROVIDER: S-EPMC10044763 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature