Molecular hydrogen promotes wound healing by inducing early epidermal stem cell proliferation and extracellular matrix deposition.

ABSTRACT:

Background

Despite progress in developing wound care strategies, there is currently no treatment that promotes the self-tissue repair capabilities. H₂ has been shown to effectively protect cells and tissues from oxidative and inflammatory damage. While comprehensive effects and how H₂ functions in wound healing remains unknown, especially for the link between H₂ and extracellular matrix (ECM) deposition and epidermal stem cells (EpSCs) activation.

Methods

Here, we established a cutaneous aseptic wound model and applied a high concentration of H₂ (66% H₂) in a treatment chamber. Molecular mechanisms and the effects of healing were evaluated by gene functional enrichment analysis, digital spatial profiler analysis, blood p

SUBMITTER: Zhao P 

PROVIDER: S-EPMC10044764 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature