Bioactive Compounds from the Mushroom-Forming Fungus Chlorophyllum molybdites.

ABSTRACT: A novel compound (1) along with two known compounds (2 and 3) were isolated from the culture broth of Chlorophyllum molybdites, and three known compounds (4-6) were isolated from its fruiting bodies. The planar structure of 1 was determined by the interpretation of spectroscopic data. By comparing the specific rotation of the compound with that of the analog compound, the absolute configuration of 1 was determined to be R. This is the first time that compounds 2-4 were isolated from a mushroom-forming fungus. Compound 2 showed significant inhibition activity against Axl and immune checkpoints (PD-L1, PD-L2). In the bioassay to examine growth inhibitory activity against the phytopathogenic bacteria Peptob

SUBMITTER: Wu J 

PROVIDER: S-EPMC10044768 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature