Elucidating collective translocation of nanoparticles across the skin lipid matrix: a molecular dynamics study.

ABSTRACT: The top layer of skin, the stratum corneum, provides a formidable barrier to the skin. Nanoparticles are utilized and further explored for personal and health care applications related to the skin. In the past few years, several researchers have studied the translocation and permeation of nanoparticles of various shapes, sizes, and surface chemistry through cell membranes. Most of these studies focused on a single nanoparticle and a simple bilayer system, whereas skin has a highly complex lipid membrane architecture. Moreover, it is highly unlikely that a nanoparticle formulation applied on the skin will not have multiple nanoparticle-nanoparticle and skin-nanoparticle interactions. In this study, we have utilized coarse-grained MARTINI molecular dynamics simulations to assess the interact

SUBMITTER: Badhe Y 

PROVIDER: S-EPMC10044770 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature