GYY4137-Derived Hydrogen Sulfide Donates Electrons to the Mitochondrial Electron Transport Chain via Sulfide: Quinone Oxidoreductase in Endothelial Cells.

ABSTRACT: The protective effects of hydrogen sulphide (H₂S) to limit oxidative injury and preserve mitochondrial function during sepsis, ischemia/reperfusion, and neurodegenerative diseases have prompted the development of soluble H₂S-releasing compounds such as GYY4137. Yet, the effects of GYY4137 on the mitochondrial function of endothelial cells remain unclear, while this cell type comprises the first target cell after parenteral administration. Here, we specifically assessed whether human endothelial cells possess a functional sulfide:quinone oxidoreductase (SQOR), to oxidise GYY4137-released H₂S within the mitochondria for electron donation to the electron transport chain. We demonstrate that H₂S administration increases oxygen consumption by human um

SUBMITTER: Star BS 

PROVIDER: S-EPMC10044827 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature