Serving Two Masters: Effect of Escherichia coli Dual Resistance on Antibiotic Susceptibility.

ABSTRACT: The prevalence of multidrug-resistant bacteria and their increased pathogenicity has led to a growing interest in metallic antimicrobial materials and bacteriophages as potential alternatives to conventional antibiotics. This study examines how resistance to excess iron (III) influences the evolution of bacteriophage resistance in the bacterium Escherichia coli. We utilized experimental evolution in E. coli to test the effect of the evolution of phage T7 resistance on populations resistant to excess iron (III) and populations without excess iron resistance. Phage resistance evolved rapidly in both groups. Dual-resistant (iron (III)/phage) populations were compared to their controls (excess iron (III)-resistant, phage-resistant, no resistance to either) for their performance a

SUBMITTER: Jeje O 

PROVIDER: S-EPMC10044975 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature