A Database of Lung Cancer-Related Genes for the Identification of Subtype-Specific Prognostic Biomarkers.

ABSTRACT: The molecular subtype is critical for accurate treatment and follow-up in patients with lung cancer; however, information regarding subtype-associated genes is dispersed among thousands of published studies. Systematic curation and cross-validation of the scientific literature would provide a solid foundation for comparative genetic studies of the major molecular subtypes of lung cancer. Here, we constructed a literature-based lung cancer gene database (LCGene). In the current release, we collected and curated 2507 unique human genes, including 2267 protein-coding and 240 non-coding genes from comprehensive manual examination of 10,960 PubMed article abstracts. Extensive annotations were added to aid identification of differentially expressed genes, potential gene editing sites, and non-co

SUBMITTER: Liu Y 

PROVIDER: S-EPMC10045015 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature