The Role of Fucoxanthin as a Potent Nrf2 Activator via Akt/GSK-3β/Fyn Axis against Amyloid-β Peptide-Induced Oxidative Damage.

ABSTRACT: Increasing evidence is suggesting that amyloid-β peptide (Aβ), a characteristic of Alzheimer's disease (AD), induces oxidative stress and mitochondrial dysfunction, leading to neuronal death. This study aimed to demonstrate the antioxidant and anti-apoptotic effects of fucoxanthin, a major marine carotenoid found in brown algae, against neuronal injury caused by Aβ. Non-toxic dose range of fucoxanthin (0.1-5 µM) were selected for the neuroprotective study against Aβ_25-35. The PC12 cells were pretreated with different concentrations of fucoxanthin for 1 h before being exposed to 10 µM Aβ_25-35 for another 24 h. The present results showed that fucoxanthin inhibited Aβ_25-35-induced cell death by recovering cell cycle arrest and decreasing intracellular reactive

SUBMITTER: Lee N 

PROVIDER: S-EPMC10045033 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature