Pre-treatment with IL-6 potentiates β-cell death induced by pro-inflammatory cytokines.

ABSTRACT:

Background

Type I Diabetes mellitus (T1D) is characterized by a specific destruction of β-cells by the immune system. During this process pro-inflammatory cytokines are released in the pancreatic islets and contribute for β-cells demise. Cytokine-induced iNOS activation, via NF-κB, is implicated in induction of β-cells death, which includes ER stress activation. Physical exercise has been used as an adjunct for better glycemic control in patients with T1D, since it is able to increase glucose uptake independent of insulin. Recently, it was observed that the release of IL-6 by skeletal muscle, during physical exercise, could prevent β-cells death induced by pro-inflammatory cytokines. However, the molecular mechanisms involved in this beneficial effect on β-cells are not yet complet

SUBMITTER: Oliveira VR 

PROVIDER: S-EPMC10045109 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature