Genome-wide identification of RNA modification-related single nucleotide polymorphisms associated with rheumatoid arthritis.

ABSTRACT:

Background

RNA modification plays important roles in many biological processes, such as gene expression control. The aim of this study was to identify single nucleotide polymorphisms related to RNA modification (RNAm-SNPs) for rheumatoid arthritis (RA) as putative functional variants.

Methods

We examined the association of RNAm-SNPs with RA in summary data from a genome-wide association study of 19,234 RA cases and 61,565 controls. We performed eQTL and pQTL analyses for the RNAm-SNPs to find associated gene expression and protein levels. Furthermore, we examined the associations of gene expression and circulating protein levels with RA using two-sample Mendelian randomization analysis methods.

Results

A total of 160 RNAm-SNPs related to m⁶A, m¹A

SUBMITTER: Wang M 

PROVIDER: S-EPMC10045113 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature