A Meta-Analysis Study to Infer Voltage-Gated K⁺ Channels Prognostic Value in Different Cancer Types.

ABSTRACT: Potassium channels are often highly expressed in cancer cells with respect to healthy ones, as they provide proliferative advantages through modulating membrane potential, calcium homeostasis, and various signaling pathways. Among potassium channels, Shaker type voltage-gated Kv channels are emerging as promising pharmacological targets in oncology. Here, we queried publicly available cancer patient databases to highlight if a correlation exists between Kv channel expression and survival rate in five different cancer types. By multiple gene comparison analysis, we found a predominant expression of KCNA2, KCNA3, and KCNA5 with respect to the other KCNA genes in skin cutaneous melanoma (SKCM), uterine corpus endometrial carcinoma (UCEC), stomach adenocarcinoma (STAD), lung adenocarcinoma (LU

SUBMITTER: Angi B 

PROVIDER: S-EPMC10045123 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature