Over-Expressed GATA-1_S, the Short Isoform of the Hematopoietic Transcriptional Factor GATA-1, Inhibits Ferroptosis in K562 Myeloid Leukemia Cells by Preventing Lipid Peroxidation.

ABSTRACT: Ferroptosis is a recently recognized form of regulated cell death involving lipid peroxidation. Glutathione peroxidase 4 (GPX4) plays a central role in the regulation of ferroptosis through the suppression of lipid peroxidation generation. Connections have been reported between ferroptosis, lipid metabolism, cancer onset, and drug resistance. Recently, interest has grown in ferroptosis induction as a potential strategy to overcome drug resistance in hematological malignancies. GATA-1 is a key transcriptional factor controlling hematopoiesis-related gene expression. Two GATA-1 isoforms, the full-length protein (GATA-1_FL) and a shorter isoform (GATA-1_S), are described. A balanced GATA-1_FL/GATA-1_S ratio helps to control hematopoiesis, with GATA-1

SUBMITTER: Trombetti S 

PROVIDER: S-EPMC10045147 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature