Combining Electrostimulation with Impedance Sensing to Promote and Track Osteogenesis within a Titanium Implant.

ABSTRACT: (1) Background: Electrical stimulation is a promising alternative to promote bone fracture healing but with the limitation of tracking the osteogenesis progress in vivo. To overcome this issue, we present an opportunity to combine the electrical stimulation of a commercial titanium implant, which promotes osteogenesis within the fracture, with a real-time readout of the osteogenic progress by impedance sensing. This makes it possible to adjust the electrical stimulation modalities to the individual patient's fracture healing process. (2) Methods: In detail, osteogenic differentiation of several cell types was monitored under continuous or pulsatile electrical stimulation at 0.7 V AC/20 Hz for at least seven days on a titanium implant by electric cell-substrate impedance sensing (ECIS). For

SUBMITTER: Engel N 

PROVIDER: S-EPMC10045247 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature