Polyphosphate Ester-Type Transporters Improve Antimicrobial Properties of Oxytetracycline.

ABSTRACT: Prolonged use of antibiotics can cause toxicity in human and animal cells and lead to the development of antibiotic resistance. The development of drug delivery systems for enhanced antibacterial properties of antibiotics could reduce toxic effects and minimize the development of resistance. The aim of this study was to evaluate the effectiveness of oxytetracycline in complexes with new polyphosphate ester-type transporters and to investigate the antimicrobial effect of these complexes on Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus growth in vitro. Two polyphosphate ester-type transporters with different molecular weights were synthesized, and oxytetracycline was attached through the phosphorus groups. To determine the sensitivities of microorga

SUBMITTER: Kozak M 

PROVIDER: S-EPMC10045294 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature