The Role of Pyrazolo[3,4-d]pyrimidine-Based Kinase Inhibitors in The Attenuation of CCl₄-Induced Liver Fibrosis in Rats.

ABSTRACT: Liver Fibrosis can be life-threatening if left untreated as it may lead to serious, incurable complications. The common therapeutic approach is to reverse the fibrosis while the intervention is still applicable. Celecoxib was shown to exhibit some antifibrotic properties in the induced fibrotic liver in rats. The present study aimed to investigate the possible antifibrotic properties in CCl₄-induced liver fibrosis in male Sprague-Dawley rats compared to celecoxib of three novel methoxylated pyrazolo[3,4-d]pyrimidines. The three newly synthesized compounds were proved to be safe candidates. They showed a therapeutic effect against severe CCl₄-induced fibrosis but at different degrees. The three compounds were able to partially reverse hepatic architectural distortion a

SUBMITTER: Ghobrial DK 

PROVIDER: S-EPMC10045301 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature