Recent Advances in Monoclonal Antibody-Based Approaches in the Management of Bacterial Sepsis.

ABSTRACT: Sepsis is a life-threatening condition characterized by an uncontrolled inflammatory response to an infectious agent and its antigens. Immune cell activation against the antigens causes severe distress that mediates a strong inflammatory response in vital organs. Sepsis is responsible for a high rate of morbidity and mortality in immunosuppressed patients. Monoclonal antibody (mAb)-based therapeutic strategies are now being explored as a viable therapy option for severe sepsis and septic shock. Monoclonal antibodies may provide benefits through two major strategies: (a) monoclonal antibodies targeting the pathogen and its components, and (b) mAbs targeting inflammatory signaling may directly suppress the production of inflammatory mediators. The major focus of mAb therapies has been bacter

SUBMITTER: Kharga K 

PROVIDER: S-EPMC10045367 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature