Dynamic Regulation Genes at Microtubule Plus Ends: A Novel Class of Glioma Biomarkers.

ABSTRACT: Glioma is the most prevalent and aggressive primary nervous system tumor with an unfavorable prognosis. Microtubule plus-end-related genes (MPERGs) play critical biological roles in the cell cycle, cell movement, ciliogenesis, and neuronal development by coordinating microtubule assembly and dynamics. This research seeks to systematically explore the oncological characteristics of these genes in microtubule-enriched glioma, focusing on developing a novel MPERG-based prognostic signature to improve the prognosis and provide more treatment options for glioma patients. First, we thoroughly analyzed and identified 45 differentially expressed MPERGs in glioma. Based on these genes, glioma patients were well distinguished into two subgroups with survival and tumor microenvironment infiltration d

SUBMITTER: Wang W 

PROVIDER: S-EPMC10045452 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature