Nitric oxide-releasing gel accelerates healing in a diabetic murine splinted excisional wound model.

ABSTRACT:

Introduction

According to the American Diabetes Association (ADA), 9-12 million patients suffer from chronic ulceration each year, costing the healthcare system over USD $25 billion annually. There is a significant unmet need for new and efficacious therapies to accelerate closure of non-healing wounds. Nitric Oxide (NO) levels typically increase rapidly after skin injury in the inflammatory phase and gradually diminish as wound healing progresses. The effect of increased NO concentration on promoting re-epithelization and wound closure has yet to be described in the context of diabetic wound healing.

Methods

In this study, we investigated the effects of local administration of an NO-releasing gel on excisional wound healing in diabetic mice. The excisional wounds of each mo

SUBMITTER: Sivaraj D 

PROVIDER: S-EPMC10045479 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature