TNF-α-Mediated Endothelial Cell Apoptosis Is Rescued by Hydrogen Sulfide.

ABSTRACT: Endothelial dysfunction is implicated in the development and aggravation of cardiovascular complications. Among the endothelium-released vasoactive factors, hydrogen sulfide (H₂S) has been investigated for its beneficial effects on the vasculature through anti-inflammatory and redox-modulating regulatory mechanisms. Reduced H₂S bioavailability is reported in chronic diseases such as cardiovascular disease, diabetes, atherosclerosis and preeclampsia, suggesting the value of investigating mechanisms, by which H₂S acts as a vasoprotective gasotransmitter. We explored whether the protective effects of H₂S were linked to the mitochondrial health of endothelial cells and the mechanisms by which H₂S rescues apoptosis. Here, we demonstrate tha

SUBMITTER: Diaz Sanchez L 

PROVIDER: S-EPMC10045727 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature