Spike patterns surrounding sleep and seizures localize the seizure-onset zone in focal epilepsy.

ABSTRACT:

Objective

Interictal spikes help localize seizure generators as part of surgical planning for drug-resistant epilepsy. However, there are often multiple spike populations whose frequencies change over time, influenced by brain state. Understanding state changes in spike rates will improve our ability to use spikes for surgical planning. Our goal was to determine the effect of sleep and seizures on interictal spikes, and to use sleep and seizure-related changes in spikes to localize the seizure-onset zone (SOZ).

Methods

We performed a retrospective analysis of intracranial electroencephalography (EEG) data from patients with focal epilepsy. We automatically detected interictal spikes and we classified different time periods as awake or asleep based on the ratio of alpha to de

SUBMITTER: Conrad EC 

PROVIDER: S-EPMC10045742 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature