Dataset Information

The effect of TNF treatment uptake on incident hospital admission in Western Australia.

ABSTRACT:

Objective

Treatment strategies for juvenile idiopathic arthritis (JIA) have shifted significantly over the last 20 years. We examined the effect of the introduction of government-subsidised TNF inhibitor (TNFi) treatment on incident hospitalisation for JIA.

Methods

Western Australian (WA) hospital data were used to identify patients < 16 years hospitalised with JIA between 1990 and 2012. Changes in the number of patients with an incident hospitalisation, overall admissions and admissions for joint aspiration were examined using join-point regression TNFi dispensing data from 2002-2012 was used to describe defined daily doses (DDD)/1000 population/day.

Results

We included 786 patients (59.2% girls, median age 8 years) with a first-time admission with JIA. The annual incident admission rate was 7.9 per 100,000 person-years (95%CI: 7.3, 8.4) which did not change significantly between 1990 and 2012 (annual percentage change (APC): 1.3, 95%CI: -0.3, 2.8). Annual hospital-based prevalence of JIA reached 0.72/1000 in 2012. DDD for TNFi usage rose steadily from 2003 indicating TNFi usage by 1/2700 children in 2012, while overall admission rates (APC 3.7; 95%CI: 2.3, 5.1) and admission rates for joint injections (APC 4.9%; 95%CI: 3.8, 6.0) also increased significantly in that period.

Conclusion

Incident inpatient admission rates for JIA were stable over a 22-year period. The uptake of TNFi was not associated with lower admission rates for JIA, due mainly to an increase in admissions for joint injection. These results indicate a notable but unexpected change in hospital-based management of JIA since the introduction of TNFi therapy in WA, where hospital-based prevalence of JIA is slightly higher than in North America.

SUBMITTER: Kelty E

PROVIDER: S-EPMC10045824 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature

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Publications

The effect of TNF treatment uptake on incident hospital admission in Western Australia.

Kelty Erin E Quintrell Ebony E Preen David B DB Manners Prue P Nossent Johannes J

Pediatric rheumatology online journal 20230328 1

<h4>Objective</h4>Treatment strategies for juvenile idiopathic arthritis (JIA) have shifted significantly over the last 20 years. We examined the effect of the introduction of government-subsidised TNF inhibitor (TNFi) treatment on incident hospitalisation for JIA.<h4>Methods</h4>Western Australian (WA) hospital data were used to identify patients < 16 years hospitalised with JIA between 1990 and 2012. Changes in the number of patients with an incident hospitalisation, overall admissions and adm ...[more]

PMID: 36973788

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Dataset Information

The effect of TNF treatment uptake on incident hospital admission in Western Australia.

Objective

Methods

Results

Conclusion

Publications

The effect of TNF treatment uptake on incident hospital admission in Western Australia.

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