Epigenetic Regulators of DNA Cytosine Modification: Promising Targets for Cancer Therapy.

ABSTRACT: Epigenetic modifications are crucial regulators of gene expression that critically impact cell lineage differentiation, survival, and proliferation, and dysregulations are commonly observed in various cancers. The aberrantly modified epigenome confers unique features on tumor cells, including sustained proliferative potential, resistance to growth-suppressive or cell death signals, augmented replicative immortality, invasion, and metastasis. As a result, epigenetic abnormalities exhibit significant impacts on all stages of oncogenesis from its onset to progression to metastasis. Among various epigenetic mechanisms in mammals, DNA cytosine methylation-demethylation is recurrently disrupted in cancers. Due to its inherent reversibility, targeting DNA methylation dynamics has gained tremendou

SUBMITTER: Jung I 

PROVIDER: S-EPMC10045866 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature