Healthy lifestyle, DNA methylation age acceleration, and incident risk of coronary heart disease.

ABSTRACT:

Background

DNA methylation clocks emerged as a tool to determine biological aging and have been related to mortality and age-related diseases. Little is known about the association of DNA methylation age (DNAm age) with coronary heart disease (CHD), especially in the Asian population.

Results

Methylation level of baseline blood leukocyte DNA was measured by Infinium Methylation EPIC BeadChip for 491 incident CHD cases and 489 controls in the prospective China Kadoorie Biobank. We calculated the methylation age using a prediction model developed among Chinese. The correlation between chronological age and DNAm age was 0.90. DNA methylation age acceleration (Δage) was defined as the residual of regressing DNA methylation age on the chronological age. After adjustment for multi

SUBMITTER: Si J 

PROVIDER: S-EPMC10045869 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature