Beyond Karl Fischer titration: a monolithic quantum cascade sensor for monitoring residual water concentration in solvents.

ABSTRACT: Quality control of liquids is an important part of analytical chemistry. The gold standard for measuring residual water in organic solvents and pharmaceutical applications is Karl Fischer titration. It has a high sensitivity, selectivity and accuracy. The downsides are a time-consuming offline analysis, together with the need for toxic reagents producing waste, and it suffers from poor inter-laboratory reproducibility. In this work, we present a high-performance lab-on-a-chip sensor exploiting mid-IR spectroscopy for liquid sensing. It is operating at 6.1 μm wavelength and is suitable for robust and flexible real-time in situ analysis of the residual water concentration in isopropyl alcohol. This is demonstrated in two experiments. A custom-made 60 μL flow cell is employed to measur

SUBMITTER: Pilat F 

PROVIDER: S-EPMC10045895 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature