Acute Pancreatitis Recurrences Augment Long-Term Pancreatic Cancer Risk.

ABSTRACT:

Introduction

In animal models, inflammation caused by experimental acute pancreatitis (AP) promotes pancreatic carcinogenesis that is preventable by suppressing inflammation. Recent studies noted higher long-term risk of pancreatic ductal adenocarcinoma (PDAC) after AP. In this study, we evaluated whether the long-term PDAC risk after AP was influenced by the etiology of AP, number of recurrences, and if it was because of progression to chronic pancreatitis (CP).

Methods

This retrospective study used nationwide Veterans Administration database spanning 1999-2015. A 2-year washout period was applied to exclude patients with preexisting AP and PDAC. PDAC risk was estimated in patients with AP without (AP group) and with underlying CP (APCP group) and those with CP alone (CP gr

SUBMITTER: Munigala S 

PROVIDER: S-EPMC10045975 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature