Bidirectional Mendelian randomization study of psychiatric disorders and Parkinson's disease.

ABSTRACT:

Introduction

Although the relationship between psychiatric disorders and Parkinson's disease (PD) has attracted continuous research attention, the causal linkage between them has not reached a definite conclusion.

Methods

To identify the causal relationship between psychiatric disorders and PD, we used public summary-level data from the most recent and largest genome-wide association studies (GWASs) on psychiatric disorders and PD to conduct a bidirectional two-sample Mendelian randomization (MR). We applied stringent control steps in instrumental variable selection using the Mendelian randomization pleiotropy residual sum and outlier (MR-PRESSO) method to rule out pleiotropy. The inverse-variance weighted (IVW) method was used to identify the causal relationship between psy

SUBMITTER: Wu Q 

PROVIDER: S-EPMC10045982 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature