How Clustered DNA Damage Can Change the Electronic Properties of ds-DNA-Differences between GAG, GA^OXOG, and ^OXOGA^OXOG.

ABSTRACT: Every 24 h, roughly 3 × 10¹⁷ incidences of DNA damage are generated in the human body as a result of intra- or extra-cellular factors. The structure of the formed lesions is identical to that formed during radio- or chemotherapy. Increases in the clustered DNA damage (CDL) level during anticancer treatment have been observed compared to those found in untreated normal tissues. 7,8-dihydro-8-oxo-2'-deoxyguanosine (^OXOG) has been recognized as the most common lesion. In these studies, the influence of ^OXOG, as an isolated (oligo-^OG) or clustered DNA lesion (oligo-^OG^OG), on charge transfer has been analyzed in comparison to native oligo-G. DNA lesion repair depends on the damage recognition step, probably via charge transfer. H

SUBMITTER: Karwowski B 

PROVIDER: S-EPMC10046028 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature