Combined Radiomodifying Effect of Fucoidan from the Brown Alga Saccharina cichorioides and Pacificusoside D from the Starfish Solaster pacificus in the Model of 3D Melanoma Cells.

ABSTRACT: Cancer is one of the main causes of human mortality worldwide. Despite the advances in the diagnostics, surgery, radiotherapy, and chemotherapy, the search for more effective treatment regimens and drug combinations are relevant. This work aimed to assess the radiomodifying effect and molecular mechanism of action of fucoidan from the brown alga Saccharina cichorioides (ScF) and product of its autohydrolysis (ScF_AH) in combination with pacificusoside D from the starfish Solaster pacificus (SpD) on the model of viability and invasion of three-dimension (3D) human melanoma cells SK-MEL-2. The cytotoxicity of ScF (IC₅₀ JB6 Cl41 > 800 µg/mL; IC₅₀ SK-MEL-2 = 685.7 µg/mL), ScF_AH (IC₅₀ JB6 Cl41/SK-MEL-2 > 800 µg/mL), SpD (IC₅₀ JB6 Cl41 =

SUBMITTER: Malyarenko OS 

PROVIDER: S-EPMC10046073 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature