The Lysophospholipase PNPLA7 Controls Hepatic Choline and Methionine Metabolism.

ABSTRACT: The in vivo roles of lysophospholipase, which cleaves a fatty acyl ester of lysophospholipid, remained unclear. Recently, we have unraveled a previously unrecognized physiological role of the lysophospholipase PNPLA7, a member of the Ca²⁺-independent phospholipase A₂ (iPLA₂) family, as a key regulator of the production of glycerophosphocholine (GPC), a precursor of endogenous choline, whose methyl groups are preferentially fluxed into the methionine cycle in the liver. PNPLA7 deficiency in mice markedly decreases hepatic GPC, choline, and several metabolites related to choline/methionine metabolism, leading to various symptoms reminiscent of methionine shortage. Overall metabolic alterations in the liver of Pnpla7-null mice in vivo largely recapitula

SUBMITTER: Harada S 

PROVIDER: S-EPMC10046082 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature