GABA_B Receptor Activation Affects Eye Growth in Chickens with Visually Induced Refractive Errors.

ABSTRACT: This study aims to explore the role of GABA_B receptors in the development of deprivation myopia (DM), lens-induced myopia (LIM) and lens-induced hyperopia (LIH). Chicks were intravitreally injected with 25 µg baclofen (GABA_BR agonist) in one eye and saline into the fellow eye. Choroidal thickness (ChT) was measured via OCT before and 2, 4, 6, 8, 24 h after injection. ChT decreased strongly at 6 and 8 h after baclofen injection and returned back to baseline level after 24 h. Moreover, chicks were monocularly treated with translucent diffusers, -7D or +7D lenses and randomly assigned to baclofen or saline treatment. DM chicks were injected daily into both eyes, while LIM and LIH chicks were monocularly injected into the lens-wearing eyes, for 4 days. Refractive error, a

SUBMITTER: Liu H 

PROVIDER: S-EPMC10046083 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature