Clinical Implications of mTOR Expression in Papillary Thyroid Cancer-A Systematic Review.

ABSTRACT: Papillary thyroid cancer (PTC) comprises approximately 80% of all thyroid malignancies. Although several etiological factors, such as age, gender, and irradiation, are already known to be involved in the development of PTC, the genetics of cancerogenesis remain undetermined. The mTOR pathway regulates several cellular processes that are critical for tumorigenesis. Activated mTOR is involved in the development and progression of PTC. Therefore, we performed a systematic review of papers studying the expression of the mTOR gene and protein and its relationship with PTC risk and clinical outcome. A systematic literature search was performed using PubMed, Embase, and Scopus databases (the search date was 2012-2022). Studies investigating the expression of mTOR in the perip

SUBMITTER: Derwich A 

PROVIDER: S-EPMC10046096 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature