A Feasibility Study of Functional Lung Volume Preservation during Stereotactic Body Radiotherapy Guided by Gallium-⁶⁸ Perfusion PET/CT.

ABSTRACT: The aim of this study was to assess the feasibility of sparing functional lung areas by integration of pulmonary functional mapping guided by ⁶⁸Ga-perfusion PET/CT imaging in lung SBRT planification. Sixty patients that planned to receive SBRT for primary or secondary lung tumors were prospectively enrolled. Lung functional volumes were defined as the minimal volume containing 50% (FV50%), 70% (FV70%) and 90% (FV90%) of the total activity within the anatomical volume. All patients had a treatment planning carried out in 2 stages: an anatomical planning blinded to the PET results and then a functional planning respecting the standard constraints but also incorporating "lung functional volume" constraints. The mean lung dose (MLD) in functional volumes and the percentage of lung v

SUBMITTER: Lucia F 

PROVIDER: S-EPMC10046099 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature