Locomotion Outcome Improvement in Mice with Glioblastoma Multiforme after Treatment with Anastrozole.

ABSTRACT: Glioblastoma Multiforme (GBM) is a tumor that infiltrates several brain structures. GBM is associated with abnormal motor activities resulting in impaired mobility, producing a loss of functional motor independence. We used a GBM xenograft implanted in the striatum to analyze the changes in Y (vertical) and X (horizontal) axis displacement of the metatarsus, ankle, and knee. We analyzed the steps dissimilarity factor between control and GBM mice with and without anastrozole. The body weight of the untreated animals decreased compared to treated mice. Anastrozole reduced the malignant cells and decreased GPR30 and ERα receptor expression. In addition, we observed a partial recovery in metatarsus and knee joint displacement (dissimilarity factor). The vertical axis displacement of the GBM+an

SUBMITTER: Aguilar-Garcia IG 

PROVIDER: S-EPMC10046174 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature