Fabrication of 3D Bioprinted Bi-Phasic Scaffold for Bone-Cartilage Interface Regeneration.

ABSTRACT: Treatments for osteochondral defects (OCDs) are mainly palliative and, with the increase in this pathology seen among both young and elderly people, an alternative treatment modality is sought. Many tissue-engineered strategies have been explored for regenerating the cartilage-bone interface; however, they generally fall short of being ideal. Although cell-laden hydrogel scaffolds are a common approach for bone and cartilage tissue regeneration, they usually lack homogenous cell dispersion and patient specificity. In this study, a biphasic 3D bioprinted composite scaffold was fabricated for cartilage-bone interface regeneration. To overcome the shortcoming of both materials, alginate-gelatin (A-G) hydrogel was used to confer a naturally occurring environment for the cells and polycaprolact

SUBMITTER: Chen H 

PROVIDER: S-EPMC10046269 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature