Potential Biomarkers and Endometrial Immune Microenvironment in Recurrent Implantation Failure.

ABSTRACT: The molecular mechanisms underlying unexplained recurrent implantation failure (RIF) remain unclear. This study aimed at identifying potential biomarkers, exploring relevant signaling pathways, and analyzing the contribution of immune cell infiltration in RIF. Microarray expression datasets were extracted from the Gene Expression Omnibus database to perform bioinformatic analyses. The results showed that ten hub genes may predict RIF with high specificity and sensitivity (area under the curve = 1.000). Protein-protein interaction analysis revealed close interactions between the hub genes and the endometrial receptivity array. The real-time quantitative polymerase chain reaction further validated three potential biomarkers (RAB32, TRIB2, and FAM155B). Functional enrichment ana

SUBMITTER: Li F 

PROVIDER: S-EPMC10046278 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature