Analysis of Cancer Genomic Amplifications Identifies Druggable Collateral Dependencies within the Amplicon.

ABSTRACT: The identification of novel therapeutic targets for specific cancer molecular subtypes is crucial for the development of precision oncology. In the last few years, CRISPR/Cas9 screens have accelerated the discovery and validation of new targets associated with different tumor types, mutations, and fusions. However, there are still many cancer vulnerabilities associated with specific molecular features that remain to be explored. Here, we used data from CRISPR/Cas9 screens in 954 cancer cell lines to identify gene dependencies associated with 16 common cancer genomic amplifications. We found that high-copy-number genomic amplifications generate multiple collateral dependencies within the amplified region in most cases. Further, to prioritize candidate targets for each chromosomal region amp

SUBMITTER: Pons G 

PROVIDER: S-EPMC10046350 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature