Intermittent Exposure to Aflatoxin B₁ Did Not Affect Neurobehavioral Parameters and Biochemical Markers of Oxidative Stress.

ABSTRACT: Aflatoxin B₁ (AFB₁) is the most common toxic mycotoxin that contaminates food. The treatment of its intoxication and the management of contaminations are a constant subject of health agendas worldwide. However, such efforts are not always enough to avoid population intoxication. Our objective was to investigate whether intermittent exposure to AFB₁ would cause any impairment in biochemical and behavioral parameters, intending to simulate an irregular consumption. Male Wistar rats received four AFB₁ administrations (250 μg/kg) by intragastric route separated by a 96-h interval. Toxicity was evaluated using behavioral tests (open field, object recognition, nest construction, marble burying, and splash test), biochemical markers of oxidative stress

SUBMITTER: Braga ACM 

PROVIDER: S-EPMC10046455 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature