Current Advances in Papillary Craniopharyngioma: State-Of-The-Art Therapies and Overview of the Literature.

ABSTRACT: Craniopharyngiomas are commonly classified as low-grade tumors, although they may harbor a malignant behavior due to their high rate of recurrence and long-term morbidity. Craniopharyngiomas are classically distinguished into two histological types (adamantinomatous and papillary), which have been recently considered by the WHO classification of CNS tumors as two independent entities, due to different epidemiological, radiological, histopathological, and genetic patterns. With regard to papillary craniopharyngioma, a BRAF V600 mutation is detected in 95% of cases. This genetic feature is opening new frontiers in the treatment of these tumors using an adjuvant or, in selected cases, a neo-adjuvant approach. In this article, we present an overview of the more recent literature, focusing on t

SUBMITTER: Jannelli G 

PROVIDER: S-EPMC10046497 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature