Epigenetic Targets in Schizophrenia Development and Therapy.

ABSTRACT: Schizophrenia is regarded as a neurodevelopmental disorder with its course progressing throughout life. However, the aetiology and development of schizophrenia are still under investigation. Several data suggest that the dysfunction of epigenetic mechanisms is known to be involved in the pathomechanism of this mental disorder. The present article revised the epigenetic background of schizophrenia based on the data available in online databases (PubMed, Scopus). This paper focused on the role of epigenetic regulation, such as DNA methylation, histone modifications, and interference of non-coding RNAs, in schizophrenia development. The article also reviewed the available data related to epigenetic regulation that may modify the severity of the disease as a possible target for schizophrenia p

SUBMITTER: Wawrzczak-Bargiela A 

PROVIDER: S-EPMC10046502 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature