Electrochemical Sensing of Urinary Chloride Ion Concentration for Near Real-Time Monitoring.

ABSTRACT: Urinary chloride concentration is a valuable health metric that can aid in the early detection of serious conditions, such as acid base disorders, acute heart failure, and incidences of acute renal failure in the intensive care unit. Physiologically, urinary chloride levels frequently change and are difficult to measure, involving time-consuming and inconvenient lab testing. Thus, near real-time simple sensors are needed to quickly provide actionable data to inform diagnostic and treatment decisions that affect health outcomes. Here, we introduce a chronopotentiometric sensor that utilizes commercially available screen-printed electrodes to accurately quantify clinically relevant chloride concentrations (5-250 mM) in seconds, with no added reagents or electrode surface modification. Initia

SUBMITTER: Nelson AM 

PROVIDER: S-EPMC10046868 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature