Comparison of Biomolecular Condensate Localization and Protein Phase Separation Predictors.

ABSTRACT: Research in the field of biochemistry and cellular biology has entered a new phase due to the discovery of phase separation driving the formation of biomolecular condensates, or membraneless organelles, in cells. The implications of this novel principle of cellular organization are vast and can be applied at multiple scales, spawning exciting research questions in numerous directions. Of fundamental importance are the molecular mechanisms that underly biomolecular condensate formation within cells and whether insights gained into these mechanisms provide a gateway for accurate predictions of protein phase behavior. Within the last six years, a significant number of predictors for protein phase separation and condensate localization have emerged. Herein, we compare a collection of state-of-

SUBMITTER: Kuechler ER 

PROVIDER: S-EPMC10046894 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature