Development of a 2-(2-Hydroxyphenyl)-1H-benzimidazole-Based Fluorescence Sensor Targeting Boronic Acids for Versatile Application in Boron Neutron Capture Therapy.

ABSTRACT: Boron neutron capture therapy (BNCT) is an attractive approach to treating cancers. Currently, only one ¹⁰B-labeled boronoagent (Borofalan, BPA) has been approved for clinical BNCT in Japan, and methods for predicting and measuring BNCT efficacy must be established to support the development of next-generation ¹⁰B-boronoagents. Fluorescence sensors targeting boronic acids can achieve this because the amount and localization of ¹⁰B in tumor tissues directly determine BNCT efficacy; however, current sensors are nonoptimal given their slow reaction rate and weak fluorescence (quantum yield < 0.1). Herein, we designed and synthesized a novel small molecular-weight fluorescence sensor, BITQ, targeting boronic acids. In vitro qualitative and quantitative properti

SUBMITTER: Kondo N 

PROVIDER: S-EPMC10046934 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature