CXCL1 and CXCL6 Are Potential Predictors for HCC Response to TACE.

ABSTRACT: Distinct immune patterns of hepatocellular carcinoma (HCC) may have prognostic implications in the response to transarterial chemoembolization (TACE). Thus, we aimed to exploratively analyze tumor tissue of HCC patients who do or do not respond to TACE, and to identify novel prognostic biomarkers predictive of response to TACE. We retrospectively included 15 HCC patients who had three consecutive TACE between January 2019 and November 2019. Eight patients had a response while seven patients had no response to TACE. All patients had measurable disease according to mRECIST. Corresponding tumor tissue samples were processed for differential expression profiling using NanoString nCounter^® PanCancer immune profiling panel. Immune-related pathways were broadly upregulated in TACE resp

SUBMITTER: Kinzler MN 

PROVIDER: S-EPMC10046993 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature